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Causes of Renal Stone Disease

There are a wide range of causes of Renal Stone Disease:

  • Idiopathic.
  • Hypercalcaemia.
  • Uric acid pathology.
  • Gastrointestinal – IBD, Bariatric Surgery.
  • UTIs.

Metabolic

  • Nephrocalcinosis.
  • Sarcoidosis.
  • Cystinuria (type A, B, AB).
  • Primary hyperoxaluria (PH).
  • Renal tubular acidosis (RTA).
  • Type I, 2,8-dihydroxyadenine.
  • Xanthinuria.
  • Lesch-Nyhan syndrome.

Structural

  • Cystic fibrosis.
  • Medullary sponge kidney (tubular ectasia).
  • Ureteropelvic junction (PUJ) obstruction.
  • Calyceal diverticulum.
  • Calyceal cyst.
  • Ureteric stricture.
  • Horseshoe kidney.
  • Ureterocoele.
  • Foreign body in the kidney e.g. retained stent.

Medicines

  • Anhydrase inhibitors.
  • Calcium supplements.
  • Vitamin C or D.
  • Probenecid.
  • Triamterene, chemotherapy.